Plenhyage XL Medium 2ml

PDRN 20 mg/ml of high molecular weight ("XL") — deeper regenerative biostimulation. Plenhyage XL line: Thin (270 PLN) · Medium (250 PLN) · Strong (285 PLN).

PDRN and polynucleotides – mechanism of action and what does "XL" mean?

PDRN (PolyDeoxyRiboNucleotide) are polynucleotides derived from salmon DNA — long-chain DNA fragments with documented biostimulating action:

• Adenosine A2A receptor activation — fibroblast stimulation to synthesise collagen, elastin and hyaluronic acid,
• Tissue regeneration — acceleration of cellular repair processes,
• Hydration — polynucleotides bind water in tissues, improving skin elasticity,
• Antioxidation — free radical neutralisation and oxidative stress protection,
• Anti-inflammatory action — inflammation reduction, healing support.

The "XL" designation indicates high molecular weight polynucleotides in the Plenhyage formula — long DNA chains provide more durable biostimulation and deeper tissue penetration compared to low molecular weight PDRN preparations.

Plenhyage XL line – variant selection

Indications and product details

• Reduction of perioral and cheek wrinkles,
• Improved firmness and elasticity,
• Revitalisation of tired and ageing skin,
• Scar reduction,
• Improved skin tone and hydration.

Product details

• Kit: 1 × pre-filled syringe 2 ml + 2 × 30G 13 mm needles
• PDRN concentration: 20 mg/ml, high molecular weight
• EAN: 1852292250048
• Manufacturer: Bioformula s.r.l., Via del Lavoro 4A/6, 20865 Usmate Velate, Italy

FAQ – questions and answers

Why does "XL" (high molecular weight) matter in polynucleotides?

Polynucleotide molecular weight directly influences biological properties. High molecular weight ("XL") polynucleotides show stronger biostimulatory effect on adenosine A2A receptors, bind water more effectively (more durable hydration) and are degraded more slowly by tissue enzymes — effects last longer. Low molecular weight preparations penetrate tissues faster but have a shorter duration of action. Plenhyage XL combines high biostimulation efficacy with effect durability.

How does Medium differ from Thin and Strong in the Plenhyage XL line?

The variants differ in preparation density (viscosity), which determines technique and area of application. Thin — lowest density, for delicate areas (periorbital, superficial mesotherapy). Medium — intermediate density: versatile variant for face, neck, wrinkles and scars. Strong — highest density, for deeper layers, heavier indications and body treatments. PDRN concentration (20 mg/ml) and molecular weight are identical across all variants — only the formulation density differs.

Plenhyage XL Medium is intended exclusively for use by doctors and cosmetologists trained in aesthetic medicine holding qualifications to perform intradermal injections. By purchasing, you confirm the required professional qualifications.

• PDRN and polynucleotides – mechanism of action and what does "XL" mean?
• Plenhyage XL line – variant selection
• Indications and product details
• FAQ